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Saturday 13 June 2015

Calotropis Procera (Aak) The Miracle Shrub in Pakistan


Therapeutic failure has been defined as a failure to accomplish the goals of treatment resulting from inadequate or inappropriate drug therapy and not related to the natural progression of disease. A lack of therapeutic effect from inadequate drug therapy may include noncompliance, recent dose reduction or discontinuation, drug–drug interaction, too low a dose of drug prescribed, and inadequate therapeutic drug monitoring. Drug therapeutic failures are responsible for increasing disease length, hospitalization time and costs, resulting in worsening of patient productivity.

The drug therapeutic failure is a very serious problem all over the world including Pakistan. It causes heavy production losses in animals. To cover the therapeutic failure, some strategic measures like the development of the new drugs as well as the herbal medicine should be introduced. Poor farmers in developing countries world-wide very often do not have access to vets or cannot afford veterinary drugs to treat their animals. This is resulting in high mortality, reduced productivity and economic losses as high as 50% of the value of their animals. For many generations, small-holder farmers and traditional healers in Pakistan have used medicinal plants to try to cure their animals. Plants have the ability to synthesize a wide variety of chemical compounds that are used to perform important biological functions. Chemical compounds in plants mediate their effects on the human and animal body through processes identical to those already well understood for the chemical compounds in conventional drugs; thus herbal medicines do not differ greatly from conventional drugs in terms of how they work. Herbal medications have the advantage of providing more than one type of ingredients at a time. These ingredients may intensify or antagonize the effect of the previous ingredients. Herbal medicines have some other advantages also. They are the chief source of medications. These are easily available to the common man and abundant in nature. So, indigenous medicinal plants may be good alternative to the medicines which are resistant to various diseases.
One of the plants which may be used as an indigenous medicinal plant is the Aak. In different languages it has different names. It is called Madar tree in English, Aakado in Gujrati, Ak in Punjabi, Madar and Aak in Urdu and Acka in Kashmiri. Aak belongs to the kingdom plantae, family Asclepiadaceae, order Gentianales, genus Calotropis and specie C. procera. The plant grows on the arid and semi-arid zone of the country. The height of this plant may be reached up to 2-3 meters. The flowers of the plant are purple spotted. Growing as a spreading shrub or a small tree, Sodom's apple milkweed (Calotropis procera) has simple stems with only a few branches, which are light grey-green in colour and covered in a fissured, corky barkThe fruit are boat shaped and very soft at the inner side. The stems, roots, leaves, flowers, barks and latex of this plant are used for different conditions. Scientist reported that parts of the plant above than the soil show the properties of cardiac glycosides, sterols, alkaloids, flavonoides and triterpenes. The various uses of the Aak are as follows.
The dry milk of Aak is used as an antidiarreheal agent. It is a good curative agent for the diarrhea. It desensitizes the gastric smooth muscle cells and highly reduces the defecation frequency. It decreases both the severity of diarrhea as well as the defecation rate. The advantage of Aak in diarrhea is that it causes to cure diarrehea but no electrolyte imbalance in the body. The dried milk of the Aak has the anticoccidial property. Aak reduces the oocyte shedding of the coccidia in feces. As an anti-coccidial agent, it helps in the normal activities of the animals, their normal appetite, regular pelleted feces and lower schizonts in the cells. The Aak also has the antithelerial property. It reduces the signs and symptoms of the thelerial infection in the cross bred cattle. The lymphnode swelling and temperature were highly reduced when used for thelirea. The Aak leaves extract has the property to kill the larvae of the mosquitoes. It is a strong larvicidal agent in marshes area. It has the property of killing the adult mosquito and also to destroy its eggs. The dry milk of the Aak has the anticancer property against tumors. It reduces the tumor growth. In one patient it increased the life span up to 4 days. It has the heat resistant protein which causes the growth inhibition of the tumor. The dry milk protein of the Aak also has the property of anticonvulsant agent. The Aak may be used in the treatment of those diseases and toxicities which causes hyperexcitement and increase in tonicity.  The dry milk protein of the Aak may also be used to induce the sleep (sedative agent). So it may be used as a preanesthetic agent in the surgeries. The Aak is also used for the treatment of blood parasites as an anti-trypniosomal agent.  In field condition Aak is also used as an anthelmintic agent. The plant has the strong anthelmintic property. It decreases the fecal eggs burden in the feces of the animals. It increases the weight gain, wool production, hide production, milk production and the reproductive performances. Aak has also the property of the hepatoprotectant agent in the Carbon tetrachloride induced liver toxicity. In conventional remedies it is used for the treatment of arthritis, by keeping it under the sole in the shoes. Aak may also be used as an expectorant agent to do the lysis of the sputum in the Chronic obstructive pulmonary disease. Aak is also used for the treatment of constipation as a purgative and laxative agent. Aak has also been used as a diuretic agent in the renal failure. Aak may also be used to decrease the pain intensity by acting as an Analgesic and antipyretic agent. Aak may also be used as an antimalarial agent. Methanolic extract of the Aak have the property of Oestogenic action and inhibit the blastocyst implantation.
  
                                

OVER 10 MILLION TONS OF ANTIBIOTIC HAD BEEN RELEASED IN THE BIOSPHERE DURING LAST 60 YEARS LEADS TO ANTIBIOTIC RESISTANCE

Antibiotics are the substances which are obtained from living organism but can stop or inhibit the activities or growth of other microorganism in high dilutions. The history of antibiotics usage is very earlier. It is thought that antibiotic concept came into being when Jhon Tendal first described the antagonistic activity of fungi against certain bacteria in England in 1875. Antibiosis was first described in bacteria in 1877 when Louis Pasteur and Robert Koch observed that air borne spores of the Bacillus can inhibit the growth of Bacillus anthracis. But it was in 1928 when the Allexander Fleming saw the antibiosis of genus penicillum against bacteria. At the last, Florey and Chain were succeeded in obtaining the first penicillin , named the penicillin G, in 1942 and so from that time the antibiotic flow started in the world. Later on, the work progressed and new synthetic antibiotic came into the practice. The first synthetic compound was sulfonamide which was developed by the Domagk in 1932 in Bayer laboratories of the Germany.
We use antibiotics for everything from treating viral infections against which antibiotics are useless to promoting the growth of livestock to curing acne. People often demand antibiotics from their doctors even in the absence of proof of a bacterial infection. And people often neglect to complete a full course of antibiotics once it has been prescribed. Due to the over usage of antibiotic in food producing animals, therapeutic efficacy of certain antibiotics started to decrease and a specific term was used for this which is called resistance. Resistance is the reduction in effectiveness of a drug in curing a disease or improving a patient's symptoms. According to the European commission report in 2005, it is estimated that over 10 million tons of antibiotic had been released in the biosphere during the last 60 years. This has exerted a very strong selective pressure for the appearance of resistance.
Antibiotic resistance was first discovered in the 1940’s when it was identified in a microorganism called Staphylococcus aureus which is resistant to penicillin. As resistant strains of bacteria emerge, they have easy passage to humans—right though the grocery store. Antimicrobial use in agriculture can also compromise human therapies when bacteria develop cross-resistance—when their resistance to one drug also makes them resistant to other, related drugs. Resistance is of two types, the first one is, Innate resistance and the second one is Acquired resistance. In innate resistance, the principles of Darwinian evolution act on bacteria with inherent resistance. Those bacteria that resist an antibiotic's effects are better suited to survive in an environment that contains the antibiotic. In the case of inherent resistance and vertical evolution, the genes that confer resistance are found on bacterial chromosomes and are transferred to the bacterial progeny every time the cell divides. Bacteria may begin life resistant to a particular antibiotic. Like Gram negative bacteria are inherently resistant to Penicillin and Vancomycin antibiotics. Bacteria that don’t begin life resistant to a certain antibiotic can acquire that resistance. In the case of vertical evolution and inherent resistance, mutations occur on chromosomes and are then selected for an environment where resistance increases fitness. In the case of horizontal evolution, genes pass from a resistant strain to a nonresistant strain, conferring resistance on the latter. For acquired resistance there are two types of mechanisms through which the organism become acquired to resistance. The first one is mutation in the genetic make up of the organism and then these mutations are selected for the resistance. In this type of resistance, any insertion deletion or substitution of the nucleotide take place which is responsible for the resistance. The second mechanism through which the acquired resistance developed is transduction, transformation or conjugation. In transduction simply a bacteriophage virus unintentionally take the DNA of the resistant bacteria and transmit it to the other bacteria. In transformation simply a bacteria rupture and transmit its genetic matrial to the next bacteria for its reproduction. In conjugation, a bridge is developed between two bacteria and genetic material flows from one bacteria to the other.
Causes of Resistance
There are many causes of resistance.
The first cause of the resistance development of bacteria against a specific antibiotic is the improper diagnosis of the disease. If a patient is not properly diagnosed, the technician give more than one antibiotics at a time and this can leads to the development of the resistance against a specific antibiotic to which it was earlier sensitive.
The second and the most important cause of the antibiotic resistance is the transmission of DNA material (plasmid) from one organism to the other without the offspring of that one. This is also called horizental gene transfer.
The third cause of the development of the antibiotic resistance is the over usage of the broad spectrum antibiotics. The use of the narrow spectrum antibiotic is preferred than the broad spectrum antibiotics. If we use the broad spectrum antibiotics the chance to survival of the sensitive bacteria increases and hence bacterial resistance to an antibiotic occurs.
The fourth cause of the bacterial resistance to an antibiotic is the unnecessary prescription. If a person takes some medicine without a need, the chance to an antibiotic resistance increases. Similarly if a patient suffering from one disease and he take another antibiotic without having an effect on the organism of the disease, the chances of antibiotic resistance increases.
The fifth cause of the antibiotic resistance is taking of lower dosage of an antibiotic than the therapeutic dosage. This leads to the development of resistance.
The sixth cause of antibiotic resistance development is the addition of antibiotics into the livestock feed and poultry feed as a daily ingredient or regular ingredient of the feed. This is the worst risk factor in the development of antibiotic resistance.
Some of the many mechanisms of resistance are indicated schematically in the following diagram
    

There are different mechanisms through which bacteria get resistance to an antibiotic. The first mechanism is the change in the permeability of the membrane. There are porin channels through which drug molecule get entrance in to the cell. Some time the protein of these channels becomes adopted and the entrance of the drug molecule into the cell decreases and hence the resistance is developed. The second mechanism for the development of the resistance is the development of the certain types of the enzymes. When a drug molecule enters into the cell, the developed enzymes degrade the drug molecule and the resistance becomes developed. The examples of such enzymes are the Betalactamases against penicillin’s and cephalosporins. The third mechanism for the development of the resistance is the change in the target protein. Target protein are those protein to which drug molecule binds and produce there pharmacological effect. Change in the target protein molecules means that no effect of the drug and hence resistance. The fourth mechanism of the drug resistance is the development of the e-flux system with repeated exposure. Some time when a drug get entry into the cell, the cell develops a pump system which pushes the drug molecule out of the cell and this is called e-flux system which is also a mechanism for the resistance.
For the prevention of the resistance to antibiotics, the following measure should be taken. When a person or an animal become sick it should be checked by the expert physician because only the expert physician will properly diagnose the disease. The antibiotic used in the treatment will only be based on the local pattern. No foreign antibiotics and vaccines should be used because it is the main cause of the resistance. Proper dose of the antibiotic should be taken. Dose lower than the normal is also the main cause of the resistance. Misuse of the broad spectrum antibiotic should be avoided. Narrow spectrum antibiotics would be preferred over the broad spectrum antibiotics. During surgery appropriate dose of the antibiotic should be used for the prophylactic purpose (prevention of the infection). Proper antiseptic protocol will also decrease the usage of the antibiotics. For the diagnosis of the disease some laboratory test should be performed for the isolation and detection of the organism. At the last development of the new antibiotics should be ensured which is based on the local pattern.

CLEANLINESS DRIVE TO COUNTER DENGUE EPIDEMIC IN PAKISTAN

Dengue is a mosquito-borne infection found in tropical and sub-tropical regions around the world. In recent years, transmission has increased predominantly in urban and semi-urban areas and has become a major international public health concern. Severe dengue was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Each year dengue affects approximately 100 millions people in the tropics and subtropics, resulting in fever, muscle and joint ache. There are four distinct, but closely related, serotypes of the virus that cause dengue (DEN-1, DEN-2, DEN-3 and DEN-4). Recovery from infection by one provides lifelong immunity against that particular serotype. However, cross-immunity to the other serotypes after recovery is only partial and temporary. Subsequent infections by other serotypes increase the risk of developing severe dengue.
In Pakistan, an outbreak of dengue was first reported in Karachi in 1994. Today the Epidemic of Dengue Viral Infections has spread severely through out the country.
This recent outbreak of dengue fever in Pakistan confirmed the presence of all four types of dengue viral infections. Two of these were reported in previous outbreaks in Karachi city, while a third has been reported in the Lahore outbreak of 2008. Now all four types of dengue serotypes have been confirmed in Punjab. In November 2010, more than 21,204 people were infected with dengue.
 Since 2011 it is increasingly becoming an epidemic in Pakistan. The disease is spreading more rapidly than the previous years. It has attracted the attention of the Government of Pakistan, especially the Punjab Government since it is widespread in that particular province of the country. As of November 2011, it has killed over 300 people in the last several months. Majority of the people died and infected are from the Lahore area in Punjab, Pakistan.
Transmission
The Aedes aegypti mosquito is the primary vector of dengue. The virus is transmitted to humans through the bites of infected female mosquitoes. After virus incubation for 4–10 days, an infected mosquito is capable of transmitting the virus for the rest of its life.
Infected humans are the main carriers and multipliers of the virus, serving as a source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the infection (for 4–5 days; maximum 12) via Aedes mosquitoes after their first symptoms appear.
The Aedes aegypti mosquito lives in urban habitats and breeds mostly in man-made containers. Unlike other mosquitoes Ae. aegypti is a daytime feeder; its peak biting periods are early in the morning and in the evening before dusk. Female Ae. aegypti bites multiple people during each feeding period.
Aedes albopictus, a secondary dengue vector in Asia, has spreaded from North America and Europe largely due to the international trade in used tyres and other goods. Ae. albopictus is highly adaptive and therefore can survive in cooler temperate regions of Europe. Its spread is due to its tolerance to temperatures below freezing, hibernation, and ability to shelter in microhabitats.

Characteristics
After being bitten by a mosquito carrying the virus, the incubation period ranges from three to fifteen (usually five to eight) days before the signs and symptoms of dengue appear in stages. Dengue Fever starts with:
  • Chills, Headache, Pain upon moving the eyes, and low backache.
  • Painful aching in the legs and joints occurs during the first hours of illness.
  • The temperature rises quickly as high as 104 F (40 °C), with relatively low heart rate (bradycardia) and low blood pressure (hypotension).
  • The eyes become reddened.
  • A flushing or pale pink rash comes over the face and then disappears.
  • The glands (lymph nodes) in the neck and groin are often swollen.
  • A characteristic rash appears along with the fever and spreads from the extremities to cover the entire body except the face.
  • The palms and soles may be bright red and swollen.
  • Fever and other signs of dengue last for two to four days, followed by a rapid drop in body temperature with profuse sweating. A second rapid rise in temperature follows.
Severe dengue is a potentially deadly complication due to plasma leaking, fluid accumulation, respiratory distress, severe bleeding, or organ impairment. Warning signs occur 3–7 days after the first symptoms in conjunction with a decrease in temperature (below 38°C/ 100°F) and include: severe abdominal pain, persistent vomiting, rapid breathing, bleeding gums, fatigue, restlessness, blood in vomit. The next 24–48 hours of the critical stage can be lethal; proper medical care is needed to avoid complications and risk of death.
Treatment
There is no specific treatment for dengue fever. Government of Pakistan and is working hard on the preventive measures to reduce the spread of the epidemic. The Government of Punjab has opened a hotline called Punjab Health Line Project for Dengue which can be reached at 0800-99000. This is to facilitate the circulation on the signs and symptoms of dengue, reach for help for suspected cases and ultimately help identify areas where the epidemic may have reached. Spraying teams have been organized for the purpose of fumigating, spraying and fogging areas where the mosquitoes have known to infect people with the virus. Supportive care with analgesics like paracetamol,  fluid replacement, and bed rest is usually sufficient. Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids should be avoided. Management of severe dengue requires careful attention to fluid management and proactive treatment of hemorrhage. There is no vaccine to protect against dengue. Developing a vaccine against dengue/ severe dengue has been challenging although there has been recent progress in vaccine development. WHO provides technical advice and guidance to countries and private partners to support vaccine research and evaluation. Several candidate vaccines are in various phases of trials.
Prevention and control
At present, the only method to control or prevent the transmission of dengue virus is to combat vector mosquitoes through:

  • Preventing mosquitoes from accessing egg-laying habitats by environmental management and modification;
  • Disposing of solid waste properly and removing artificial man-made habitats;
  • Heavy monsoon rains in Punjab provide ideal conditions for dengue-carrying mosquitoes to thrive in stagnant waters. This mosquito breeds in fresh water (rainy water in air cooler, at roofs, flower pots etc). So covering, emptying and cleaning of water storage containers must be done on a weekly basis;
  • Applying appropriate insecticides to water storage outdoor containers;
  • Using of personal household protection such as window screens, long-sleeved clothes, insecticide treated materials, coils and vaporizers;
  • Improving community participation and mobilsation for sustained vector control;
  • applying insecticides as space spraying during outbreaks as one of the emergency vector control measures;
  • Active monitoring and surveillance of vectors should be carried out to determine effectiveness of control interventions.

What is “strangles?”

Equine strangles (also known as equine distemper) is a highly infectious disease that affects the upper respiratory tract of equine (horses, donkeys, and mules). Strangles is named from the air restriction in late stages of the disease where the horse breathes as if it is being strangled because of the restriction of the trachea due to swollen lymph nodes. It is considered to be one of the top three most significant and feared respiratory diseases in horses. It accounts for close to 30% of all equine infections reported worldwide; making it the most frequently encountered single horse illness.

ETIOLOGY:

The pathogen responsible for this disease is the bacteria named Streptococcus equi. The bacteria are generally spherical and form long chains, or colonies. They are considered facultative anaerobes, where oxygen is not needed for their survival. The bacteria are able to remain viable while frozen and live for several weeks outside of the body.

How serious is it?

Most animals are fully recovered from strangles in 2 to 4 weeks. Although enduring immunity against re-infection is variable – in some equids it can last for years. However, not all horses develop a protective immunity upon recovery. Some horses, although they appear healthy, shed the bacteria for a prolonged period and can infect nearby horses. Horses can die from strangles due to asphyxiation or “strangling”, as well as from other complications.

How common is strangles?

Because strangles is highly contagious it spreads rapidly from animal to animal, and is one of the more common bacterial infections of horses.

How does it spread?

The disease is spread via nasal secretions (snorting, coughing, physical nose-to-nose contact) and pus from draining abscesses. It is also possible for humans to spread the disease, through contaminated clothing, hands or equipment etc.

What should I watch for?

Typical clinical signs begin with mild lethargy, decreased appetite, slight cough, nasal discharge and a fever. A higher than normal rectal temperature in adults is over 100.5F or in foals over 101.5F .In most cases, a few days after the onset of fever and more mild signs, the lymph nodes swell and form abscesses around the throat, as well as in some cases under or around the base of the ear. At first, the nasal discharge is clear then becomes cloudy and whitish. After the abscesses ruptured and drained into the nasal passages the discharge usually becomes thick white to yellow. Horses are often seen positioning their heads low and extended in order to relieve the throat and lymph node pain. Abscesses may rupture through the skin. Be aware that the pus from the nose and draining abscesses is highly contagious to other horses. Not all cases develop the “classic” abscess formation. Without complications, recovery typically begins after abscesses drain or the infection begins to be resolved by the body.

If I suspect my horse has strangles, what should I do?

The first thing to do is to isolate any horse with signs of strangles from other horses. Supportive care of the animal includes:

Keep the horse dry and protected from extreme cold or heat

Provide soft, palatable feed

Monitor horse’s body temperature

Contact your veterinarian to describe the signs being shown by the horse and get their advice on further management of the horse’s illness, including treatment options

Apply hot compresses to abscesses to promote rupture and drainage

How can I minimize the risk of Strangles at my facility?

Have a biosecurity policy for people and horses coming onto your operation and avoid contact with horses of unknown health status or those that are ill.

Don't overstock your equine facility.

If new horses are introduced, request a statement by a veterinarian regarding their health status and recent exposure to contagious diseases. Keep them isolated for a few weeks to observe them for signs of illness.

Personnel attending to horses must take precautions to not move from isolated horses to the other horses on the establishment.

Don't share tack, feed tubs, water containers, trailers, pens, or stalls used by horses of unknown health status.

The organism is not thought to have extended persistence in the environment; however the exact duration of persistence is not known. Surfaces that are nonporous can be cleaned with soap and water, rinsed and then disinfected. Consult with your veterinarian regarding how best to disinfect surfaces in an equine facility. Special attention should be paid to the water containers that may have been contaminated with pus from ill horses.

Horses with a history of strangles can be tested to determine if they are shedding Strep. equi. Ask your veterinarian about the need for such testing of new arrivals.

What should I do if I have a strangles outbreak in my horses?

Contact your veterinarian, stop horse movement until the outbreak is resolved, and work with your veterinarian to determine a possible need for follow-up visits to check for bacterial shedding.

POST NATAL CARE OF THE PUPPIES

1. Very little care is required of the owner of the puppies during the first few weeks after birth. Natural instinct causes the mother to provide for most needs of the offspring. the best advice is to leave the new family alone as much as possible and simply watch for anything you feel might be abnormal .

2. Be sure puppies nurse within the first 2-6 hours following birth. This provides the antibodies which fight against diseases in the pup for the first 6-8 weeks of life. These antibodies are only absorbed during the first few hours of birth. 

3. Maintain the warm environment. Room temperature should be maintained at a minimum of 72 degrees F. Remember that it’s about 10 degrees colder on the floor (since heat rises) than eye level. 

4.Avoid drafts and keep warm. Dampness and chilling can be FATAL to young puppies. Recommend placing a heating pad set on LOW temperature underneath 1/3 to ½ of the nesting box. Do not place heating pad in direct contact with the puppies. 

5. A properly nourished pup sleeps most of the time, stays quiet, and has a full stomach. Pups should sleep, wake up, cry, feed, and go back to sleep. Extended crying is not normal and may be a sign of problems: Such as no milk available in the breasts, infected milk (mastitis), the mother dog not letting the pups nurse, or a problem with the puppy being able to nurse properly. 

6. Tail Docking and Dewclaw Removal is routinely done at 3-5 days of age at our hospital. 
Eyes usually open at 10-14 days of age. Swollen eyes or discharges should be reported to Doctor when observed. 

7. Puppies should be brought to the hospital at 3 weeks of age for routine deworming of intestinal parasites. 

8. Being weaning the puppies at 3-4 weeks of age. Recommended mixing puppy food with warm water and milk replacer to achieve a watery gruel. As the puppies being eating this better, you can slowly make the consistency of the gruel thicker and thicker. IT IS VERY IMPORTANT that the puppies be allowed to nurse the mother dog until they are eating solid food readily. They can be allowed to nurse the female until 6-8 weeks of age. 

9. The weight and size of the pups should be monitored daily, with all of them gaining approximately the same amount of weight daily. If one or two pups are smaller than the others, or are not growing as rapidly, the mother may be pushing them away and refusing to nurse them. Recommended that you supplement the feedings of these pups with puppy milk replacer. DO NOT use human milk. 

10. Vaccinations and heartworm preventive for the puppies are recommended at 6-8 weeks of age. The puppies do have some protective antibodies from the mother, but his may not be a strong enough protection against diseases like PARVO and DISTEMPER. 
Observe the mother dog and pups for the presence of fleas. On very small pups, even 5-6 fleas could potentially cause serious blood loss. Contact our office for instructions on fleas treatment for the mother dog and her offspring. 
Be sure that the bedding and nesting area are cleaned daily to help prevent infection.

HEAT STROKE A BURNING ISSUE IN DOGS DURING HOT WEATHER

Heat stroke is a serious condition resulting from extremely high body temperature (rectal temperature of 105 to 108 degrees Fahrenheit). Summer month often have days that are extremely hot (and it seems as though the weather has become "too hot - too fast").Heat stroke in dogs is not all that uncommon. Dogs do not have an efficient method of handling heat stress because they wear their fur coat all year long and they do not sweat. Abnormally high body temperature (also called hyperthermia) develops after increased muscular activity with impaired ability to give off heat, due to high heat and humidity or respiratory obstruction. Allowing a dog to remain in a car with closed windows on a hot summer day is probably the most common cause of heat stroke. Normal dogs dissipate some heat from their skin; however, panting allows evaporation of water from the respiratory tract and is an effective method of heat dissipation. When these mechanisms are overwhelmed, hyperthermia and heat stroke usually develop. Heat stroke is most common in the large breeds and in dogs with short noses, so mastiffs are in the group of dogs that are most susceptible to this problem. The most common clinical signs of heat stroke are weakness, loss of balance, excessive panting, roaring breathing sounds, excessive salivation, decrease in mental awareness, collapse and coma and even Death from heat stroke can occur pretty quickly. 

 First Aid
 
Immediate treatment is critical to success when dealing with heat stroke, so delays are potentially harmful, or fatal. Immediate give bathes or rinses of cool water (not cold water). If the water is too cold or if ice is used to cool a heat stroke victim, it can cause a decrease or loss of skin circulation, which can delay cooling. Use fans, take him to air conditioning, or sponge the groin area, tummy area, wet his tongue, place rolled up wet towels against his head, neck, tummy, and between his legs. When his temperature drops to 104 F or 103 F, stop cooling efforts. Cooling too fast or too much can cause other problems and Once  your pet  is stabilized  get him to a veterinarian  for further check up and supportive treatment.

Prevention

Here are few tips to prevent this problem in your dog.

1.    Exercise your dog gradually. Don't over do it. Don't go for a five-mile run on the first nice day of the season. This is especially true if your dog is older, obese or has a heart or lung problem.

2.    If it is hot and your dog is panting hard - stop what you are doing. Allow him to cool down and stop panting before continuing.

3.    ALWAYS make sure your dog has plenty of fresh clean water available.

4.    NEVER EVER leave your dog inside a hot car, period not for 20 minutes, even not for 2 minutes. If it is hot outside, don’t take your dog with you stay in the car with him and keep the air conditioner running.

5.    Remember - if you are uncomfortable, your pet probably is, too.

PET PIGEONS AND DOVE ARE VERY PEACEFUL AND THOSE KEPT AS PETS WILL EVEN SEEK OUT AFFECTION FROM THEIR HUMAN FAMILY!

Domesticated doves and pigeons like human contact. They are quiet and peaceful, and make wonderful pets. Pet Pigeons and all types of doves have a subtle appeal due to their special characteristics. Most have a pleasant voice. It is generally a 'cooing' sound and most have about 4 or 5 types of calls. The strut of these adorable birds is accompanied with head nodding.

When pigeon breeds and doves take flight, they take off with a whirring sound. These breeds were noted early on for their flying behaviors which include aerial acrobatics as well as a homing instinct.

These birds can be quite entertaining as well as useful. Throughout history they have been used to carry messages, and were known as carrier pigeons. The homing instinct is still employed today.

The homing instinct is demonstrated today in the popular use of white pigeons for wedding releases. (Note: the birds used in Weddings are White Pigeons, not White doves. White Pigeons are a larger bird with a developed homing instinct that the White Dove lacks.) It has also influenced the popular sport of racing pigeons, or 'Pigeon Racing'.


DISTRIBUTION:
                                  Doves and pigeons are found throughout the world except in the Polar Regions. A large portion of them are established in the Oriental and Australasian regions. It is not known when these birds first became kept in captivity, but they have been bred and hybridized for various purposes for thousands of years. Specialized traits such as the homing instinct, aerial acrobatics, and unique feather structures have been developed (or diminished) through selective breeding over many years.
 It is not known what the total number of doves and pigeons is, though there are over 305 described living species. In the pigeon fancy alone there have been over 200 different breeds developed.
Paintings and hieroglyphics have many references to doves and pigeons from today back to as early as about 2600 BC. Aristotle writes about pigeon sports around 350 BC. These birds have been used for thousands of years for food, sport, and as message carriers.
   Pigeon racing is a worldwide sport developed due to the homing instinct as well as acrobatic flying abilities. These birds were selectively bred to intensify these as well as other traits and there were many local strains. The first exhibits were held toward the end of the 19th century.
DESCRIPTION:
                               There is no scientific separation between doves and pigeons. They are often simply recognized as one or the other by the common names given to them over the years. In general the term 'pigeon' is usually applied to the larger species and 'dove' to the smaller species.
Pigeon and Dove Sizes:
These birds come in a vast array of sizes, from those that are about the size of a sparrow to those that are the size of a large chicken.
Pigeon and Dove Colors:
 Though they are not the most brightly colored birds, many doves and pigeons are very attractive. There is a variety of colors and color patterns, ranging from whites to blue grays and any shade in between, and a variety of uniquely feathered types.
Pigeon and Dove Shape:
Doves and pigeons generally fall into one of two body types, those with a long slender body and those that are short and plump. The larger birds are especially characterized by deep-chested bodies and are fairly muscular. They all have relatively small heads and short, usually scaled legs. Their beaks are relatively small, short, and narrow with a tip that is slightly bent down. Their nostrils are wide open and the cere is featherless.
Pigeon and Dove Life Span:
 Doves and pigeons will live for a relatively long period of time, generally about 10 to 12 years with some living quite a bit longer. A Turtle Dove was recorded to have lived for 34 years.
There are many pigeon breeds and types of doves available. A wide variety of pet doves, as well as pet pigeons and show pigeons, can be found in the pet industry and through breeders. The types of doves and pigeon breeds include:
Barbary Dove
Green Wing Dove
Senegal Dove
Spotted Dove
Bleeding-heart Pigeon
Brunner Pouter Pigeon
Budapest Tumbler Pigeon
Chinese Owl Pigeon
Crested Pigeon
English Trumpeter Pigeon
Indian Fantail Pigeon
Maltese Pigeon
Oriental Frill Pigeon
Purple-breasted Fruit Pigeon
Rock Pigeon - Common Pigeon
Valencian Figurita Pigeon
West of England Tumbler Pigeon

CARE AND FEEDING:
                                                  In the wild doves and pigeons feed on seeds, berries, fruits, green leaves and shoots, spiders and other insects. The birds described here are the seed eaters in the subfamily Columbinae. The fruit eaters are in the subfamily Treroninae, but are not often seen in captivity probably because feeding them is much more difficult.
The seed eaters fall into three categories; those that feed only in trees and shrubs, those that are ground feeders, and those that feed in both places.
Bird Food:
A dove and pigeon diet consisting of a basic commercial mix supplemented with greens rich in minerals is generally regarded as suitable. Greens can include such things as lettuce, endive, chickweed, clover, watercress, and spinach. Some fruits are berries, apple, and pear. For smaller doves and pigeons you can use a budgie or canary mix. The smaller birds will also enjoy millet spray.
  Foods available for doves and pigeons include seed only diets, formulated diets that are either pelleted or extruded, and commercial mixes generally consisting of seed, cereal, and legumes. The commercial mixes and the seed only diets require supplements for complete nutrition.
Though formulated diets offer the same nutrients as commercial mixes as well as the necessary vitamins and minerals, they have been found to cause loose stools. This is probably because of the addition of molasses, but because of this problem they are not widely used today.
Supplements:
Grit and Gravel:
Because they eat seeds whole, doves and pigeons need grit and gravel. The little stones and the grit help grind up harder seed in the gizzard.
Vitamins: Vitamins can be added to the water or sprinkled on food in a dry form about once a week.
Calcium:
Offer calcium in the form of crushed oyster shell, grit, and even cuttlebone for the small birds.
Other Supplements:
 Some folks like to occasionally offer game bird crumbles, water soaked dog biscuits, and water or milk soaked bread as well

Water:
            
Fresh water must be provided every day. Doves and pigeons drink water by sucking it up and swallowing it rather than throwing their heads back like other birds do. One of the best ways to provide water, and to keep the birds from soiling it, is to use a so-called 'automatic' waterer, an upside down container that feeds into a tray type base.
Bird Baths:
The personal hygiene of doves and pigeons includes a bath followed by sunning and preening themselves. Some like to bathe while others prefer a shower, and then there are some who like a dust bath. A shower can be accomplished with either a hand held sprayer or a hose with a fine spray head and lukewarm water.

Bird Grooming:
When they preen themselves, many have 'powder feathers' rather than an oil gland found in many other birds. They use their beak to spread the powder over their feathers. They molt once a year replacing just a few feathers at a time, not all at once. During this time the molt starts with the wing feathers first, the body molts throughout the period, and the tail feathers molt last.
Wing clipping is not necessary and is not recommended for doves and pigeons. Unlike the parrot families, these birds cannot climb to safety and depend on flight.

  

Housing:
   In all cases the size of the dove or pigeon determines the size of its home, they must be able to flap their wings without hitting the sides. Small birds such as the Diamond dove can be housed in a cage. The medium and larger sized birds will do much better in an aviary. Birds that are allowed free flight will need a dovecote. Unlike the larger birds, many of the small doves have very poor homing instincts and will not do well if released outside. They are not good candidates for free flight housing.
  • Bird Cages:
Generally a rectangular cage is better than a square one and the bar spacing must be small enough that the bird cannot get its head through. Because many of these birds spend a good deal of time on the ground, a wire bottom cage should have part of it covered with paper or even grassy sod. They also prefer a partially enclosed or box-type cage for a sense of security. Keep the cage in a bright draft-free area but not in direct sun. Normal room temperatures are fine with humidity at 50-70%.Some people wish to cover the cage at night. This is not necessary unless the cage will be in an area where the lights will be turned on and off at night. A cover in this case can help keep the bird from getting frightened.
  • Aviary:
       An outdoor or breeding aviary needs to have a protected shelter that can be heated and cooled where necessary. Orienting the aviary to the south or southwest helps as these birds need good daylight and will avoid dark areas.
       The shelter should be taller than the flight area as many of these birds will seek out the highest place to roost for the night. A good shelter size is about 6' (2 m) square and 8' (2.5 m) high. Provide a flat shelf mounted as high as possible for roosting and for nest building, as well as some regular perches or natural branches. Provide some nest boxes for those birds that prefer an enclosed nest. A platform with a rim, mounted about 3' above the ground, is a good place for food and water.The flight area is a good place to provide a shallow pool for bathing and will need perches. You can provide nesting boxes in the flight if you locate them in areas where there are trees and bushes close by so the birds get a sense of security. Leave plenty of room for flying. Flight areas for small birds can be about 6' (2 m) long, 3' (1 m) wide, and 6' (2 m) high. For medium size birds it can be about 9' (3 m) long, 6' (2 m) wide, and 6' (2 m) high. For the large birds it can be 15' (5 m) long, 6' (2 m) wide, and 6' (2 m) high.

  • Dovecote:
     
    Free flight birds will need a dovecote. For many years doves and pigeons have been allowed free flight. 'Dovecotes' or 'pigeon lofts' were included as an integral part of many buildings throughout Europe. Originally these were built for utility purposes and later became more ornamental. There are many examples of these still today. A dovecote is a natural way to keep birds that have a homing instinct and will return to the dovecote each evening.

       For free flight birds, probably the most important thing to consider is safety! Free flight birds can be at risk from a variety of predators. Birds that are not use to free flying are especially at risk.
Free flyers must first be accustomed to their home before allowing them to fly. If they are new to the dovecot, you can put a mesh cover around it until they become familiar with their accommodations. Once they know their home and where their food is they will return in the evening. It is recommended that you feed them sparingly in the morning, providing the bulk of their feed in the evening to encourage them to return.

MAINTENANCE:
                                    The basic bird cage or aviary care includes daily cleaning of the water and food dishes, and bathing bowls. Weekly you should wash all the perches and platforms. Periodically disinfect the entire bird house and accessories with a mild bleach solution. A total hosing down and disinfecting of an aviary should be done yearly, replacing anything that needs to be freshened such as old dishes, nests, and perches.

SOCIAL BEHAVIORS:
                                               In the wild all types of doves and pigeon breeds are known to flock, some do it only seasonally while others flock year round. Most species will live together peaceable if they are given plenty of room. In too small an area they can be very aggressive as well as during breeding season. All doves and pigeons can be somewhat territorial, and there are some species that are extremely so and very aggressive. Be sure to research the behaviors of the birds you want before putting them together with others.
   Be very careful about adding a new bird to a cage with existing birds. Most doves and pigeons are territorial by nature. They may be protective of their space and will not appreciate a new roommate, possibly even killing the newcomer.
 Many species can be house with other birds in an aviary, such as finches and parakeets, but aggressive species should be housed separately. Doves and pigeons do not mix well with cats, nor do they do well with dogs.
HANDLING/TRAINING:
                                            Young birds that are raised in an aviary can become very affectionate once they get used to their home and their family. This is the ideal pet as it will become quite tame and devoted while wild doves and pigeons generally remain cautious and on their guard. The wild birds will be shy and reserved and will seldom become overly affectionate.
When you first bring your bird home, give it about a week or so with very little disturbance and don't let it out of its cage. There is much for it to become familiar with just being in its cage. Give it a chance to know you and get comfortable.
   After it is comfortable with you and its accommodations, then you can let it out to start exploring the rest of the home. Doves and pigeons enjoy time out of the cage daily. A pet dove can become very people oriented.

BREEDING/REPRODUCTION:
                                                               
Doves and pigeons have a very strong reproductive drive and many will breed indoors. In general the tropic or subtropic species are the easiest to breed. All the birds in this family are monogamous, meaning they mate for life. However they will generally take another mate if something happens to permanently remove the chosen mate. Sometimes a male will kill his mate.
  • Sexing:
     
    For pigeon and dove breeding you will need a sound compatible pair. Many doves and pigeons are not easily sexed though there are a few species that are dimorphic, having distinctive markings differentiating the male from the female. If the sex is not visually obvious, it can be be determined by either a surgical probe, endoscopy, which can be done by many veterinarians or by a DNA testing, usually a blood sample or a few plucked feathers sent to be diagnosed in a lab.
       Most breeders will keep young birds in a pen together until after the first molt and let them pick their own mate. This usually works, though sometimes what you think is a pair is two of the same sex. If a pair lays three or more eggs, then you have two hens.
  • Nest:
      
    These birds are noted for building rather flimsy nests. In the wild they will construct a nest or platform using a few twigs, grasses, roots, and maybe a few leaves. They will often build their nest on a rocky ledge or in the branches of trees or shrubs, but sometimes they just use the old nest of others doves and pigeons or other birds.For many species you can provide a nest platform or a shallow box, pan, or basket. For the hole nesting birds provide a nest box. Nesting materials for the smaller species can be such things as grass hay, coconut fibers, and moss. For the larger species it can be twigs, pieces of willow, birch, moss, and straw. Fill half the nest with material and put some on the platform to encourage nesting. Both parents will help with the nest building to some degree.
  • Egg Laying and Hatchlings:
The female will generally lay two eggs and both parents will incubate (though the female does most of it) for 13 to 19 days. There is usually one of each sex if both eggs hatch The hatchlings are fed by both parents on a special food called 'crop milk' for the first 4 or 5 days, and then the crop milk becomes mixed with more solid food. Crop milk is a combination of partially digested food and a curd like substance from the parents crop. The young will fledge in about 12 to 20 days. It is important to provide plenty of water for the parents when they are feeding young.
  • Pigeon - Dove Breeding Problems:

There can be difficulties in breeding if the pair is very young. There are some species such as the Bleeding-heart Pigeon that are difficult to breed or may abandon their eggs or hatchlings. In this case you can often successfully foster the eggs or young to other birds that are not so particular about breeding and are good parents. This can work if the eggs or hatchlings are within 4 or 5 days of the foster parents own. You must also be sure they eat a similar diet and that they are similar in size. Some very good foster parents include the Barbary Dove, Diamond Dove, Senegal Dove, Spotted Dove and some of the fancy pigeons.
   Due to their very high reproductive drive, hybridization from cross-breeding two species can happen in a community aviary. Be sure you take precautions to keep the birds you want breeding within their own species.

10 NUTRITIONAL TIPS FOR PET HORSES

1. Base Your Horse’s Diet on Grass and Hay.
    A horse’s digestive system is made to process large quantities of grass, which is high in fiber and water. The basic diet for most horses should consist of grass and good-quality hay that’s free of dust and mold. As a general rule, companion horses should be able to graze or eat hay whenever they want to.

2. Feed Several Small Meals a Day
    Because horses’ stomachs were developed for grazing, horses function better with a feeding plan based on “little and often.” Experts recommend that horses should eat several small meals at least two, preferably three or more, in the course of a day. When feeding hay, give half the hay allowance at night, when horses have more time to eat and digest.

3. No Grain, No Gain
     Most horses, even fairly active ones, don’t need the extra calories found in grains. Excess grains can lead to muscle, bone and joint problems in young and adult horses. Unless directed otherwise by your veterinarian or other equine professional, it’s best to feed low-energy diets high in grass and hay.

4. Be Aware of Individual Needs
    Feed according to the individuality of the horse, including condition and activity level. Some horses have difficulty keeping on weight, and need more feed per unit of body weight. However, most horses should eat between 2 percent to 4 percent of their body weight daily in pounds of hay or other feeds. Your veterinarian can help you decide how and what to feed your horse.

5. Water Works
    Plenty of fresh, clean, unfrozen water should be available most times, even if the horse only drinks once or twice a day. Contrary to instinct, horses that are hot from strenuous exercise should not have free access to water. Rather, they should be allowed only a few sips every three to five minutes until they have adequately cooled down.

6. Provide a Supplementary Salt Block
    Because most diets do not contain mineral levels high enough for optimal health and performance, horses should have free access to a trace mineral and salt block. This will provide your horse with adequate levels of salt to stabilize pH and electrolyte levels, as well as adequate levels of trace minerals. As long as plenty of fresh water is available, you needn’t be concerned about over consumption of salt.

7. Take it Slow
     Any changes in the diet should be made gradually to avoid colic (abdominal pain usually associated with intestinal disease) and laminitis (painful inflammation in the hoof associated with separation of the hoof bone from the hoof wall), either of which can be catastrophic. Horses are physically unable to vomit or belch. Overfeeding and rapid rates of intake are potential problems. Consequently, a horse or pony that breaks into the grain bin, or is allowed to gorge on green pasture for the first time since autumn, can be headed for a health disaster.

8. Dental Care & Your Horse’s Diet
    Horses need their teeth to grind grass and hay, so it is important to keep teeth in good condition. At the age of five years, horses should begin annual dental checkups by a veterinarian to see if their teeth need floating (filing). Tooth quality has to be considered when deciding whether or not to feed processed grains (grains that are no longer whole, such as cracked corn and rolled oats). Horses with poor dental soundness, a particular problem in older horses tend to benefit more from processed feed than do younger horses, which have sounder mouths and teeth.

9. Exercise Caution
    Stabled horses need exercise. Horses will eat better, digest food better and be less likely to colic if they get proper exercise. Horses should finish eating at least an hour before hard work. Do not feed grain to tired or hot horses until they are cooled and rested, preferably one or two hours after activity. You can feed them hay instead. To prevent hot horses from cooling down too quickly, keep them out of drafts or warm in blankets.

10. Don’t Leave Home without It

      Because abrupt dietary change can have devastating results on a horse’s sensitive system, you should always bring your horse’s food with you when you travel. Additionally, some horses will refuse to drink unfamiliar water, so you may also want to bring along a supply of the water your horse regularly drinks.